Sleep and Synaptic Renormalization: A Computational Study
نویسندگان
چکیده
منابع مشابه
Sleep and synaptic renormalization: a computational study.
Recent evidence indicates that net synaptic strength in cortical and other networks increases during wakefulness and returns to a baseline level during sleep. These homeostatic changes in synaptic strength are accompanied by corresponding changes in sleep slow wave activity (SWA) and in neuronal firing rates and synchrony. Other evidence indicates that sleep is associated with an initial reacti...
متن کاملSleep and synaptic homeostasis.
In the last decades a substantial knowledge about sleep mechanisms has been accumulated. However, the function of sleep still remains elusive. The difficulty with unraveling sleep's function may arise from the lack of understanding of how the multitude of processes associated with waking and sleep-from gene expression and single neuron activity to the whole brain dynamics and behavior-functiona...
متن کاملSleep and Wakefulness in the Cuneate Nucleus: A Computational Study
We present a computational study about the in uence of the sensorimotor cortex on the processing of the cuneate nucleus during sleep as well as wakefulness. Realistic computational models were developed supported by experimental data obtained from intact-brain preparations in cat. Furthermore, a physiologically plausible circuit is proposed and predictions under both di erent cortical stimulati...
متن کاملNeuronal - Based Synaptic Compensation : A Computational Study in Alzheimer
In the framework of an associative memory model, we study the interplay between synaptic deletion and compensation, and memory deterioration, a clinical hallmark of Alzheimer's disease. Our study is motivated by experimental evidence that there are regulatory mechanisms that take part in the homeostasis of neuronal activity and act on the neuronal level. We show that, following synap-tic deleti...
متن کاملNeuronal-based synaptic compensation: a computational study in Alzheimer's disease.
In the framework of an associative memory model, we study the interplay between synaptic deletion and compensation, and memory deterioration, a clinical hallmark of Alzheimer's disease. Our study is motivated by experimental evidence that there are regulatory mechanisms that take part in the homeostasis of neuronal activity and act on the neuronal level. We show that following synaptic deletion...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2010
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.00593.2010